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We analyzed the top 100 weight loss products sold on Amazon and found that the popular weight loss ingredients in the US market are mainly: apple cider vinegar, caffeine, green tea extract, coffee bean extract (chlorogenic acid), L-carnitine and Dietary fiber (soybean fiber, wheat dextrin, maltodextrin, fructooligosaccharides, etc.).

1) Apple cider vinegar 

Apple cider vinegar is made from crushed apple juice, first fermented with yeast to produce alcohol, and then further fermented with bacteria (Acetobacter) to convert the alcohol into acetic acid. Apple cider vinegar is very popular in the U.S. market, and has ushered in explosive growth in the U.S. market for two consecutive years. In 2020 and 2021, the annual growth rate of retail sales in the U.S. mainstream multi-channel herbal supplements best-selling raw materials list has exceeded 120 for two consecutive years % (133.8% in 2020, 128.6% in 2021). Apple cider vinegar helps with weight loss. In 2007, a study of a group of people with type 1 diabetes found that those who took apple cider vinegar had slower gastric emptying (the speed at which food moves from the stomach to the small intestine).it can help people feel fuller for a longer period of time, thereby reducing overall food intake. In addition, a study found that apple cider vinegar can inhibit obesity-induced oxidative stress in high-fat-fed rats by regulating the antioxidant defense system, and reduce the risk of obesity-related diseases by preventing atherosclerosis.

2) Caffeine

Caffeine, whose chemical name is 1,3,7-trimethylxanthine, is an alkaloid derivative, which can keep people excited by stimulating nerves. Caffeine can promote the decomposition of fat, increase the body's metabolism to a certain extent, and at the same time increase the consumption of heat energy, so as to achieve a certain weight loss effect.

There are some reports that caffeine can increase the expression of mitochondrial uncoupling protein 1 (UCP1) in obese mice (this protein is an important substance in the process of brown adipose tissue heat production), Ksenija et al. from the University of Nottingham, UK published in "Scientific An article on "Reports" gave the observation of caffeine's stimulation of UCP1 in vitro studies, which further proved the promotion effect of caffeine on brown adipose tissue.

Cellucor Super HD weight loss supplement with added green tea extract, capsicum extract, caffeine, N-acetyl-L-tyrosine, amla extract, dandelion root extract, yohimbe bark extract and more.