Introduction

Levomefolic acid (INN) (also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active. 
It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) also known as methionine synthase (MS). 
L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml). 
Levomefolic acid (and folic acid in turn) has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with fDump, a metabolite of the drug fluorouracil. 

English Name: L-5-MTHF-Ca

Specification: 99%

Other Name: Levomefolate calcium; Nutrifolin;

Bodyfolin;L-5-MTHF-Ca;L-5-Methyltetrahydrofolate calcium;L-5-Methyletrahydrofolate calciuM;

Cas No.: 151533-22-1

Molecular Formula: C20H23CaN7O6

Molecular Weight: 497.51800

Appearance: White powder

COA: Yes

MOA: Yes

Flow Chart: Yes

Packing

Original: 25kgs/Drum, inner by plastic bag

Net Weight: 25kgs/Drum

Gross Weight: 28kgs/Drum

Drum Size & Volume: I.D.42cm × H52cm, 0.08 m³/ Drum

Shipping

1. DHL, FEDEX, UPS, POST, EMS and TNT for quantity less than 50KG;

2. Sea shipping for quantity over 500KG;

3. Air shipping is available for 50KG above;

4. For high value products, please select air shipping and air express for safe;

5. All logistics line if you need DDU and DDP, and you can avoid do Custom Clearance by yourself.

Storage: Stored in cool and dry places. Keep away from strong light and heat

Shelf Life: 2 years if stored properly.

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